Tranexamic Acid to Prevent and Treat Post-Inflammatory Hyperpigmentation

Post-inflammatory hyperpigmentation (PIH) is a common skin condition that can occur after an inflammatory event, such as acne, eczema, psoriasis, or a skin injury. PIH is characterized by the darkening of the skin due to an excess production of melanin, which can lead to unsightly marks and blemishes. In recent years, tranexamic acid has gained attention as a promising treatment for PIH. In this blog post, we will discuss what tranexamic acid is, how it works, and the scientific evidence supporting its use in preventing and treating PIH. 

What is Tranexamic Acid? 

TXA

Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine. It was first approved by the FDA in 1986 to treat excessive bleeding during surgery or in patients with bleeding disorders. TXA works by inhibiting the breakdown of blood clots, which can help reduce bleeding. In recent years, TXA has gained attention as a potential treatment for PIH due to its ability to inhibit the production of melanin in the skin. 

  

How Does Tranexamic Acid Work? 

The exact mechanism of how TXA works to treat PIH is not yet fully understood, but several studies have suggested that it works by inhibiting the activation of plasmin, a protein that can stimulate the production of melanin in the skin. When plasmin is activated, it can break down fibrin, a protein that helps to maintain the integrity of blood vessels. This breakdown of fibrin can lead to increased blood flow and the release of growth factors that stimulate the production of melanin. By inhibiting plasmin activation, TXA can help to reduce the production of melanin and prevent the formation of PIH. 

Preventing Post-Inflammatory Hyperpigmentation with Tranexamic Acid 

Several studies have investigated the use of TXA to prevent PIH. In a randomized, double-blind, placebo-controlled study, researchers examined the efficacy of TXA in preventing PIH in patients with melasma. Melasma is a type of hyperpigmentation that is commonly seen in women and is thought to be triggered by hormonal fluctuations, such as those that occur during pregnancy or while taking oral contraceptives. The study found that the use of TXA significantly reduced the incidence of PIH in patients with melasma compared to placebo. 

Another study investigated the use of TXA as a prophylactic treatment for PIH in patients undergoing laser treatment for acne scars. The study found that the use of TXA prior to laser treatment significantly reduced the incidence of PIH compared to placebo. The researchers concluded that TXA may be a promising prophylactic treatment for PIH in patients undergoing laser treatment. 

  

Treating Post-Inflammatory Hyperpigmentation with Tranexamic Acid 

TXA has also been investigated as a potential treatment for PIH. In a randomized, double-blind, placebo-controlled study, researchers examined the efficacy of TXA in treating PIH in patients with melasma. The study found that the use of TXA significantly reduced the severity of PIH in patients with melasma compared to placebo. 

Another study investigated the use of TXA as a treatment for PIH in patients with acne. The study found that the use of TXA significantly reduced the severity of PIH in patients with acne compared to placebo. The researchers concluded that TXA may be a promising treatment for PIH in patients with acne. 

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Skin Type: Normal
Comments: Any ideas on how to get rid of brown skin damage
Skin defence

Marks of sun damage are still there they haven't faded much after using twice a day for 60 days. . I will continue until product is finished. I'm a bit disappointed

Skin Type: Combination

I am so happy that I stumbled upon clearly basics on instagram. I was skeptical at first but decided to give it a try and bought clear out clarifying lotion. It's been 2 months and my skin has improved a lot. I can see significant reduction in pores and acne.

Skin Type: Combination
Amazing

After years of medication and products, I decided to try clearly basics. In just 6 weeks my skin has calmed and I am now able to treat scarring.

So glad to have found these products!

Finding products that helped to control my acne without irritating my sensitive skin has always been a huge challenge. The clearly basics products have been my saviour, I can't recommend them enough ☺️

⭐️⭐️⭐️⭐️⭐️Excellent and actually works

I am so incredibly impressed with the TLC for pore minimising - it 💯 works and has transformed my skin.

I’m in my 50’s and always had hormonal flare ups with larger pores as I age - this is a game changer and have just reordered my 3rd bottle !

❤️❤️❤️❤️

Skin Type: Sensitive / Dry
The only moisturiser I trust

I am super sensitive and this is the only moisturiser that I trust honestly incredible.

Skin Type: Combination
Amazing!

I use this product and with the clear out and it has really helped my hormonal acne.

Skin Type: Sensitive / Dry
Here one day, gone the next!

After success with Clearly Basics for my acne scars, I stocked up with all of the active acne products to prepare myself for how angry my acne would get when going off hormonal birth control. I have tried and failed twice as my acne comes back so bad that I just start taking it again. This time I have been using clearly basics without fail every day (lighten up and clear out). I have had 3 pimples start to form and I use ‘Stop Spot’ and the next day instead of a much redder, much angrier pimple with a big white head - the pimple is gone! I have been very happy with this product. I’m one month down (typically when acne gets the worst) - let’s do this!

I love that these products are gentle on my daughter skin.

This skin care routine is the o lay one that has helped clear up my daughters skin.

My daughters skin is really starting to look better!

Skin Type: Oily
So far so good

Bought this for my daughter that has struggled with acne for years. She has seen improvement and less frequent breakouts.

Best moisturizer I have found!

V
Lighten Up Redness Rescue Cream
Veronica Ilenya Ranieri
Skin Type: Sensitive / Dry
Perfect

Has changed my skin from acne pro to almost perfect 😍😍

Skin Type: Combination
Obsessed !!

Obsessed with this cleanser!! It left me feeling fresh and prevented break outs. It is incredible . Loved this product so much

My skin feels so soft after using this moisturiser!

My skin feels so soft after using this moisturiser!

Skin Type: Combination
Fresh and clean!

My face is filled with energy and feels so fresh and clean!

Skin Type: Normal
excellent item!

have been using this for years! so good for my skin :)

C
So Fresh pH Balancing Cleanser
Carmelinda Di Manno
Skin Type: Combination
Fresh Feeling

My skin feels so clean and still hydrated when I use this cleanser. It’s balancing and refreshing. My skin has responded really well to it and at times my skin can be sensitive. I highly recommend this product to anyone with relatively oily t-zone area

Skin Type: Combination
Very happy!

Love the texture, the minty scent and the lather.
I wish the bottles were a bit bigger HOWEVER they are just small enough to fly with.

Skin Type: Normal
Comments: The only thing I now need to use to keep my skin clear.
The holy grail for clearing hormonal acne.

This is the only product that I have needed to keep my skin clear since discovering it about 2 years ago, after suddenly developing cystic hormonal acne at the age of 25. I now only need to use it every second night, so it's incredibly affordable. It has also never irritated my sensitive skin and it has faded previous acne marks to truly clear my skin. After years of trying expensive supplements/products/harsh prescription creams, Clear Out was the only thing that gave me long-lasting results.

Skin Type: Oily
Clearly Basics is the only product that has helped my Adult Acne

I have always struggled with dehydrated acne prone skin. Every month like clockwork I would get a new breakout on my chin or cheek area. These included large cystic acne that by the time they came to a head would take me months to clear. With new breakouts each month this created more & more spots before the first could heal leaving more hyper pigmentation spots that never have time to clear. Clearly basics changed all that for me. It gave my skin a chance to heal and reduced the number of breakouts each month. When I do get a new breakout it resolves itself quickly with less scarring and redness. Now that the acne is under control the products are helping to eliminate the remaining hyper pigmentation spots left from years of acne. I have not been using the product for long but I will continuing relying on this product and look forward to the day I can happily look in the mirror at a smooth clear & even complexion some day soon.

Skin Type: Combination
Comments: Product consistency in terms of smoothness/coarseness/stickiness/ is sometimes a miss, don't believe it affects the result provided.
Great Combo

Have seen great improvements by using these 2 items concurrently, hard to fault and wil continue purchasing.

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